Immunoreactivity of Cytomegalovirus-Induced Fc Receptors
نویسندگان
چکیده
منابع مشابه
Heartache of fc receptors.
diopathic dilated cardiomypathy (DCM) is characterized y the progressive depression of cardiac function and left entricular dilation in the absence of coronary artery disease. here is evidence to suggest that humoral immunity plays n important role in the pathogenesis of DCM. In particlar, the role of autoantibodies in the pathogenesis of DCM as been emphasized (1). Sera from patients with DCM ...
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Cytomegalovirus (CMV) and other viruses within the herpes group have recently been shown to induce Fc receptors in infected monolayers. We have examined the possibility that such receptors might facilitate the adherence of antibody-coated bacteria to CMV-infected cells. To do this, we infected confluent human embryonic lung (HEL) cell monolayers with CMV (strain AD 169) and then used a double r...
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Immunoglobulins and Fc receptors are critical glycoprotein components of the immune system. Fc receptors bind the Fc (effector) region of antibody molecules and communicate information within the innate and adaptive immune systems. Glycosylation of antibodies, particularly in the Fc region of IgG, has been extensively studied in health and disease. The N-glycans in the identical heavy chains ha...
متن کاملBinding of human and animal immunoglobulins to the IgG Fc receptor induced by human cytomegalovirus.
Human cytomegalovirus (HCMV)-infected cells express a virus-encoded receptor that is able to bind the Fc part of IGG: Some basic binding properties of this Fc receptor (FcR) have been examined. The affinity constant (K(a)) for human IgG Fc fragment in its interaction with acetone-fixed, HCMV-infected human embryonic lung fibroblasts was estimated to be around 2 x 10(8) M(-1) and the number of b...
متن کاملThe human cytomegalovirus Fc receptor gp68 binds the Fc CH2-CH3 interface of immunoglobulin G.
Recognition of immunoglobulin G (IgG) by surface receptors for the Fc domain of immunoglobulin G (Fcgamma), FcgammaRs, can trigger both humoral and cellular immune responses. Two human cytomegalovirus (HCMV)-encoded type I transmembrane receptors with Fcgamma-binding properties (vFcgammaRs), gp34 and gp68, have been identified on the surface of HCMV-infected cells and are assumed to confer prot...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 1987
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.1987.tb03105.x